Which condition is explicitly listed as a caution for Timolol in the source material?

Which condition is explicitly listed as a caution for Timolol in the source material?

• A. Sickle cell disease
• B. Asthma
• C. Diabetes
• D. Hyperthyroidism

Answer: (A)

Timolol can be absorbed systemically from eye drops and block beta receptors throughout the body. In sickle cell disease, crises are often precipitated by hypoxia, dehydration, or acidosis, and the body's ability to respond to stress can be important in preventing vaso-occlusion. Beta-blockade from Timolol can blunt cardiovascular and respiratory compensatory responses, potentially worsening oxygen delivery to tissues and increasing the risk of a vaso-occlusive event. That’s why the source material explicitly lists sickle cell disease as a caution with Timolol.

Timolol can be absorbed systemically from eye drops and block beta receptors throughout the body. In sickle cell disease, crises are often precipitated by hypoxia, dehydration, or acidosis, and the body's ability to respond to stress can be important in preventing vaso-occlusion. Beta-blockade from Timolol can blunt cardiovascular and respiratory compensatory responses, potentially worsening oxygen delivery to tissues and increasing the risk of a vaso-occlusive event. That’s why the source material explicitly lists sickle cell disease as a caution with Timolol.